Spain is undefeated in 23 matches across all competitions, but was forced to stage comebacks in two draws during the group stage, while Russian Federation tries to bounce back from a 3-0 loss to Uruguay as +190 underdogs when they make their first knockout stage appearance since 1986.
Russian Federation are hoping for a World Cup miracle on Sunday as the host nation take on 2010 winners Spain for a place in the quarter-finals after Cristiano Ronaldo and Lionel Messi exited the tournament.
As well as losing the World Cup final four years ago, Messi has tasted defeat in the final of the Copa America on three occasions.
After an eventful evening watching Argentina squeeze past Nigeria in the group stage, Diego Maradona was back in the centre of attention as his beloved Argentina met France in the World Cup's Round of 16 on Saturday.
However Ronaldo, who will be 37 by the time of the next World Cup, would not be drawn on whether he planned to extend his worldwide career.
That early morning June 30 game delivered a 3.9/12 in metered market ratings and 5.2 million for the Rupert Murdoch owned network. The 24-year-old is yet to win silverware with Tottenham, but last season was his best yet as he surpassed the 40-goal mark for the first time. When the 2020 World Cup rolls around, Messi will be pushing 35. His inability to score in the knock-out phase of any World Cup is a telling statistic.
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Ronaldo was powerless to stop European champions Portugal exiting Russian Federation 2018 on Saturday as Edinson Cavani's brace sent Uruguay into the quarter-finals. He was the third top scorer for the club in Ligue 1, after Cavani (28) and Neymar (19); and was level with Neymar in the highest number of assists (16) in the French league.
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His devilish pace and clinical finishing have certainly made him a player to be feared in Russian Federation.
An iconic figure has, however, remained a passionate follower of his nation's fortunes and was a lively presence in the stands throughout their campaign in Russian Federation.
Uruguay who put up a robust defensive performance in the game will now meet France in the quarter-final match.
His goals against Costa Rica and Mexico have taken him to 57 for Brazil (he is behind only Pele and Ronaldo in their all-time scoring charts) and he will be desperate to add to that tally when they face Belgium in the last eight.