"For us to be out there for that amount of time, I really hope we can address this", the South African, who won the fifth set 26-24 to beat Isner, said. The final score: 7-6 (6), 6-7 (5), 6-7 (9), 6-4, 26-24.
He was made to wait an hour and 18 minutes longer for his wish to finally come true.
"I don't really know what to say right now", Anderson told the BBC.
Isner now holds the record for the top two longest matches ever played at Wimbledon - this one second only to the American's epic 11-hour, 5-minute classic against Nicolas Mahut in 2010.
Anderson and Isner's main strength is their service game, which was pretty apparent given that three sets went to a tie-break.
Kveta Peschke, 43, and her American partner Nicole Melichar advanced with a 6-3, 4-6, 7-5 victory over Gabriela Dabrowski and Yifan Xu.
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The 36-year-old starred on the series before retiring from Hollywood when she became a member of the royal family. Come Saturday, all eyes will be on her sister, Kate, who will join Meghan in cheering on Serena Williams .
Djokovic, meanwhile, is seeking a fifth final at the All England Club and 22nd at the Slams. In the six-plus hour match, he served 53 aces and hit 129 winners.
That moment, which took 99 grueling games to reach, sent the 32-year-old South African through to the final on Sunday, where he will play one of two legends of the sport, Novak Djokovic and Rafael Nadal. The final set alone lasted two hours and 50 minutes.
For perspective, the longest Major League Baseball game this season lasted 5 hours and 48 minutes.
Isner had won the last five meetings with Anderson but their history together goes even further than their first professional encounter back in 2008. "We want to see Rafa!"
In contrast, Anderson didn't concede a break-point in this set, taking one of the six offered by Isner under fading light. The record, funnily enough, was set by Isner. Anderson is a righty, prompting the Wimbledon crowd collectively gasp at the play. Rather than giving up the point and settling for 15-15, Anderson scrambled to his feet, picking up his racket with his left hand and sending back a forehand return.
When two tall men, one 6ft 8in and the other taller by two inches, armed with games that are built around their huge commanding serves, face off against each other, the match nearly invariably proceeds along at least some foreseeable lines.
Quotable: "I like the level of tennis that I'm playing on right now. I felt like I did some good business here in the past already", he said.