"Lock and secure all homes, other buildings, and vehicles left behind to the extent possible and monitor updates from local authorities", the Siskiyou County Sheriff's Department said.
The Klamathon Fire started on July 5 near Hornbook, California, a town 14 miles south of the OR border, according to KSBY.
The fire is now zero percent contained and is "fast-moving", Eliason said.
The county issued a local emergency declaration, saying the fire "is causing conditions of extreme peril to the safety of persons".
While the fire was growing quickly Thursday afternoon a 20 to 26 miles per hour south wind was pushing it along the Interstate.
Fire personnel spent the night and morning in pitched battle against the Holiday fire, which exploded Friday night amid 100-degree temperatures and risky "sundowner" winds that made the blaze impossible to control.
The blaze consumed an estimated 20 structures, including homes and other types of buildings.
The 400-acre brush fire is swallowing up homes in the densely populated suburb of Alpine and it's only 4 percent contained.
Nathan's Hot Dog Eating Contest held on Coney Island
Nathan's Hot Dog Eating Contest is now considered one of the biggest and most famous competitive eating events in the world. Miki Sudo said after eating 37 dogs and buns that the heat may have slowed her down in winning the women's competition.
Hundreds of evacuation orders have been put in place, and flames have already reached multiple structures.
Thousands were told to evacuate as the fire edged into residential areas, and by late on Friday night it was about 1.6 kilometres from the downtown area, county fire Captain Dave Zaniboni told U.S. media.
About 75 miles east of Los Angeles, a wildfire in the San Bernardino National Forest prompted mandatory evacuations for the entire community of Forest Falls, which has about 700 homes and about 1,000 residents.
Meanwhile, in Santa Barbara County, firefighters were battling a new "fast-moving and wind-driven" blaze, known as the Holiday Fire.
On Saturday morning, Eric Durtschi looked at the charred remains of his rented hilltop home in Goleta.
350 fire personnel were battling the blaze from ground and air.
San Diego Gas and Electric says almost 1,700 customers are without power after the fire damaged the electric system.
Dozens of fires have broken out across the western United States, fanned by scorching heat, winds and low humidity.
The largest fire burning in the state is known as the County Fire, and has scorched more than 88,000 acres in Napa and Yolo counties.