Photo taken on September 2, 2018 shows the fire and smoke rising from the Mazzeh airbase in the Damascus' western Mazzeh neighborhood, Syria, on September 2, 2018.

An air strike near a United States base in southeastern Syria has killed at least eight pro-government fighters, the Syrian Observatory for Human Rights reported Monday.

According to unnamed officials and intelligence sources cited by multiple media outlets, the air base was the target of an airstrike or missile attack, and Syrian air defenses responded.Some reports suggested that there had been three explosions, targeting a research center in Jamraya near Damascus and a military depot, which suffered a direct hit.

Several strikes against the Syrian government or allied forces have been in the past attributed to USA forces deployed as part of a multinational coalition against the Islamic State (IS) group. The Syrian Observatory for Human Rights said that two military men were killed and another 11 were wounded.

AFP's correspondents in Damascus heard multiple blasts overnight, one of which lit up the sky in a deep red hue, but reported calm on Sunday morning.

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In May, Israel said it had attacked Iranian military infrastructure in Syria following what it said was an Iranian rocket attack on Israeli-held territory.

"The IDF (Israel Defence Forces) will continue to take strong and determined action against Iran's attempts to station forces and advanced weapons systems in Syria", Prime Minister Binyamin Netanyahu said.

In July, Syria accused Israel of bombing a military post in the northern province of Aleppo, where the Observatory reported at least nine pro-regime fighters died.

Syrian government forces are planning a phased offensive in Idlib and surrounding areas held by insurgents fighting Assad, who has been backed by both Russian and Iranian forces in the country's civil war.

Syrian troops are supported military by their Russian and Iranian allies, as well as by Lebanese Hezbollah fighters and Iraqi, Iranian and Afghan militiamen.