Travis Head, Aaron Finch and Marnus Labuschagne are making their debut for Australia. Last time Australia played three debutants in the same Test was quite recent at Adelaide against South Africa in November 2016 - Matt Renshaw, Peter Handscomb and Nic Maddinson.
Pakistan's Haris Sohail struck his maiden Test century as they ended the second day of the first Test against Australia with a lead of 452 in Dubai on Monday.
Australia suffered a dramatic collapse on the third day to hand the advantage back to Pakistan in the first Test in Dubai.
Opener Imam-ul-Haq was unbeaten on 23 while nightwatchman Asif was dismissed for nought, unable to guard Azhar from coming to bat in a crucial stage.
Another run out resulted in the wicket of Safraz Ahmed (15) before the tourists wrapped up the tail and left their batsmen with an unenviable 13 overs to face after a long day in the field.
After resuming their first innings at the overnight score of 255/3, Pakistan lost night-watchman Mohammad Abbas (1) early.
Australia will now heavily depend on Nathan Lyon and Jon Holland to trigger a collapse but with 325 runs already in their kitty, Pakistan will fancy their chances clearly having already caused a psychological dent in the first innings.
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Aubameyang, who scored the final two goals of a 5-1 rout of Fulham on Sunday, is adamant that the north London side can extend their winning run.
In a spell of 22 balls Asif took four wickets as Australia slumped to 180-5 by tea.
Khawaja hit eight fours before miscuing a premeditated sweep and was caught at short leg while Finch had five boundaries and a six in his knock.
Yasir went wicketless after 28 probing overs.
Khawaja, the Pakistan-born batsman, improved upon his previous best score in Asia of 26, made against Sri Lanka at Galle in 2011, by reaching his 13th Test half-century.
The second match of the two-Test series will be played in Abu Dhabi (October 16-20).