It seems that the 100GB - or 112GB to be precise - is simply required for the installation process, and the final size of the game will in fact be around 55GB.
Weighing in at an astonishing 50GB in download size, those who pick up the game physically are going to have to wait hours (or days for some) before they're able to play through the entirety of the game's content.
The developer confirmed that yes, a day one patch is required in order to play traditional multiplayer, Zombies, or the Specialist Headquarters mode. It's a hefty amount of data to expect players to download straight away.
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As such, if you were planning on picking up a physical copy of Black Ops 4, you could be waiting a little while before you can jump into the full experience. The download version of Black Ops 4 is only slightly larger, around 55GB, so yeah, depending on your Internet speed, buying physical will save you maybe...10 to 30 minutes? Despite that, the devs have recommended that you have about 112 GB of space free on your hard drive. However, this is not an accuarate representation of the actual patch size, just the space needed to install it.
The only upside is that Blackout, the new Battle Royale mode, becomes playable once the install is around 30% done. The patch itself will be approximately 50 GB. If you've pre-ordered the digital version of the game then you'll be all set to go as the game will go live with the patch already included.
Black Ops 4 officially releases on Friday, October 12 and the servers are expected to go live in the United Kingdom on Thursday afternoon.