Shortly before the vote, Trump said Kavanaugh "will be a great justice of the Supreme Court".
There was also an outburst as Sen.
A townhouse near the Washington residence of Republican Senator Susan Collins, whose backing for Kavanaugh helped get him over the line on Saturday, flew the flag of her home state ME upside down in protest. The judge has vehemently denied the allegations.
Trump is expected to watch the vote play out from aboard Air Force One as he flies to Kansas.
Kavanaugh was confirmed as the 114th justice of the Supreme Court by a vote of 50-48.
He accuses Democrats of doing "everything in their power" to make Kavanaugh's nomination about something other than his judicial record and qualifications.
Two other women accused him in the media of sexual misconduct in the 1980s.
The outcome, telegraphed Friday when the final undeclared senators revealed their views, was devoid of the shocks that had come nearly daily since Christine Blasey Ford said last month that an inebriated Kavanaugh tried to rape her at a 1982 high school get-together.
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And in a statement issued soon after Collins spoke, Manchin explained he was supporting Kavanaugh notwithstanding the "serious accusations" leveled against the judge and lingering questions about Kavanaugh's temperament. While most Democrats opposed the confirmation of Neil Gorsuch the year before, Kavanaugh immediately attracted sterner opposition because opponents feared he was even more likely to roll-back key decisions such as Roe v Wade, which has guaranteed a woman's right to a legal abortion. Grassley says he's glad senators had the courage to "stand against the politics of personal destruction".
Coming ahead of the crucial November 6 mid-term elections, the conformation of Kavanaugh as Supreme Court judge, albeit with a short majority, gives a major moral and political victory to President Donald Trump and his ruling Republican party.
The vote on confirming Kavanaugh as an associate justice will begin at roughly 3:30 p.m., and senators have been advised to be in their seats by the time the historic roll call begins. Some disrupted the vote in the Senate chambers.
In a twist, Murkowski voted "present" Saturday as a courtesy to Republican Kavanaugh supporter Steve Daines, who was to walk his daughter down the aisle at her wedding in Montana.
Hours before the vote, scores of protesters broke through barricades and staged a raucous sit-in protest on the US Capitol steps.
Many people climbed the stairs before they were removed by the police.
U.S. Sen. Chris Murphy, who also opposed Kavanaugh, said on Twitter that he is "furious" with Kavanaugh's confirmation and that "it will change our country forever".
The crowds outside the court have been chanting "Vote them out!
Truly, Judge Kavanaugh's confirmation is a low moment for the Senate, for the Court, for the country", Schumer said.