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Valbuena, 33, and Castillo, 37, were playing in a Venezuelan winter baseball league and were teammates on the Cardenales de Lara.

MLB veterans Jose Valbuena, 34, and Jose Castillo, 37, lost their lives in a vehicle crash after a playing in a Venezuela Professional Baseball League game.

Castillo played for the Pittsburgh Pirates, San Francisco Giants and the Houston Astros between 2004 and 2008. Known for his affinity for bat flips and an ebullient personality, Valbuena was a popular clubhouse fixture in his decade-plus as a Major Leaguer - as evidenced by the outpouring of emotional messages from former teammates on social media.

"This is a very sad day for our sport as we mourn the deaths of Luis Valbuena and Jose Castillo", commissioner Rob Manfred said in a statement. He also played for the Mariners, Indians, Cubs and Astros during an 11-year career that began in 2008. He finished his career with a.226 batting average with 114 home runs and 367 RBIs. He was a productive player on the field and played a key role in the Astros run to the postseason in 2015.

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Castillo debuted in Major League Baseball in 2004 and played four seasons for the Pittsburgh Pirates.

Our thoughts are with the families of both Luis Valbuena and Jose Castillo.

The Venezuelan professional baseball league announced all three scheduled games Friday were cancelled and it said flags will fly at half-staff in all stadiums for three days.