The shooter sped off in a pickup truck, police said. He was taken to a hospital, where he was pronounced dead, an NYPD official told HuffPost.
Witnesses said they heard six or seven shots.
Shea says Cali emerged from his home around 9:15 p.m. after the suspect backed his pickup truck into Cali's Cadillac SUV.
The body of mafia crime boss Paul Castellano lies on a stretcher outside the Sparks Steak House in NY after he and his bodyguard were gunned down December 16, 1985.
Citing a source in NY law enforcement, the outlet reports that Cali was respected for his personal family ties to Italy, his traditional Mafia values and his low-profile style - a contrast to the flamboyant decades under John "The Teflon Don" Gotti, who irked New York's other crime families by attracting scrutiny, and column inches, with murders and a series of splashy trials marked by witness intimidation and other tactics.
NY media reported that 53-year-old Cali was shot multiple times outside his auto on Staten Island on Wednesday evening, local time, by an unidentified man who then fled the scene in a blue vehicle.
AFP 2018 OLIVIER MORIN'Mafia Can't Become Extinct Because It's a Type of Behaviour- Criminologist
He had pleaded guilty in an extortion conspiracy involving a failed attempt to build a NASCAR track in Staten Island. Castellano was the last New York City crime boss to be gunned down, and Gotti later died in prison in 2002.
The Gambino family is one of New York's five historic Italian Mafia families - along with the Genovese, Lucchese, Colombo and Bonanno families.
Chief of Detectives Dermot Shea said there has been a slight urise in alleged mob-related violence in NY within the a year ago. "Very surprising, but I guess old habits die hard".
Paul Castellano in 1959.
The Gambino family was once considered the biggest organised crime group in the United States, the New York Times reports, but began to decline after Gotti and other senior figures were jailed.
One of the most notorious gangs of NY is at the center of a new mob murder mystery. For that, he got 16 months in prison before he was released.
Man United gets Barcelona in Champions League quarterfinals
Liverpool have previously taken part in six quarter-finals in the Champions League era, all of which have been post-2000. How can I watch the draw? 17 April, second legs: Manchester City v Tottenham and Porto v Liverpool .