The five-time Balon d'Or victor also drew a blank in prior quarter-final clashes with Juventus, twice against Atletico Madrid and in Barca's 2015 tie with PSG.
Man United or Barcelona vs.
Liverpool were drawn to play FC Porto in the knockout rounds for the second year in succession, as Ajax's reward for eliminating the holders Real Madrid is a two-legged tie against Cristiano Ronaldo and Juventus. This tie looks like Liverpool all the way.
Students young and old lead climate strike march to Maltese parliament
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"I could not be further away from thinking it's the best draw because it isn't - it is just the draw, it's the opponent we have to prepare for and that's all we will be thinking about from when we start preparing for the game". My standards are not thinking, 'We are Manchester City, we have to win everything.
Five-time champion Liverpool got a rematch against Porto, the team they beat in the last 16 last season. Mauricio Pochettino's team are a threat on their own, but playing in their spectacular new ground could give them an extra edge.
Manchester United's tie against Barcelona means caretaker manager Ole Gunnar Solskjaer will enjoy another trip to the Nou Camp, where he scored the victor in United's Champions League final win over Bayern Munich in 1999.
At the draw at the Uefa headquarters in Nyon, Switzerland on Friday, the draw also pitted Premier League title challengers Liverpool against Portuguese club Porto, and Italian champions Juventus against Dutch side Ajax. "Now we know it, let's prepare". There are six teams in the Premier League and we can not say they are bad because all of them are in quarter-finals [Arsenal and Chelsea are in the last eight of the Europa League]. But for United to reach the semifinals for the first time since 2011, they will have to pull off one of the biggest results in their European history.